Comparative Fluoride Release and Antimicrobial Analysis of Commercial and Experimental Bioactive

Nadia Aman; Hashmat Gul; Maleeha Nayyer; Mehreen Gilani; Azad Ali Azad; Asma Tufail Shah; Aqif Anwar Chaudhry; Muhammad Kaleem; Abdul Samad Khan

Abstract:

Objectives  The objectives were to measure fluoride release and assess the antimicrobial behavior of fluoride-doped nano bioactive glass (F-nBG) and nano zinc oxide (ZnO)-enriched novel dentifrices. Materials and Methods  Experimental dentifrices were synthesized by incorporating ZnO nanoparticles and F-nBG (1.5 wt% and 4 wt%) as active ingredients. The fluoride release behavior of suspensions and elutes of samples were analyzed by ion selective electrode. Antimicrobial activity and minimum bactericidal concentration against Streptococcus mutans and Lactobacillus casei were evaluated. Microbial stability against contamination was also assessed by a challenge test. Results  The fluoride release behavior of experimental dentifrices was higher than that of commercial dentifrices and was dependent on filler loading. The fluoride release was more from suspensions than elutes. Zones of inhibition (ZOIs) and minimum bactericidal concentration values for novel dentifrices showed direct proportionality with filler loading, and effectiveness was exhibited against both strains. Experimental dentifrices exhibited effective antibacterial potential, which could possibly be due to release of sufficient fluoride and zinc ions in aqueous media from F-nBG and ZnO present in their formulations.

research from:

• Foundation University College of Dentistry

Year:

2020

Type of Publication:

Article

Journal:

European Journal of Dentistry

Volume:

14

Number:

1

Pages:

38-44

Month:

2

DOI:

10.1055/s-0040-1701292