Background:To determine the accuracy of magnetic-resonance-cholangio-pancreatography (MRCP) in comparison with the endoscopicretrograde-cholangio-pancreatography (ERCP) in the diagnosis of bile duct pathologies . Methods: Patients with suspected pancreaticobiliary pathologies having a clear indication for ERCP were included in this prospective study. MRCP was performed, using a torso phased-array coil.ERCP was performed by duodeno-videoscope and general electric fluoroscopy. MRCP were reviewed by radiologist who was blinded to the ERCP results.The ERCP was interpreted by an experienced consultant gastroenterologist also blinded to the MRCP results. Results of hepatopancreatico biliary system from both techniques were compared, according to the pathology found, e.g. choledocholithiasis, pancreatico-biliary strictures and dilatation. The sensitivity, specificity, and positive and negative predictive values were calculated. Statistical significance was set at p<0.05, with 95% confidence intervals. Results. MRCP had sensitivity, specificity, positive and negative predictive values of 87%, 80%, 83.3% and 84.2% respectively for choledocholithiasis, which correlates well with results obtained in other parts of the world. Conclusion. MRCP has high diagnostic accuracy for bile duct calculi and is a useful non-invasive technique to diagnose biliary pathologies and avoids unnecessary ERCPs and its complications. Key Words: MRCP, ERCP, Hepato-PancreaticoBiliary Pathologies