The pathogenesis of different congenital anomalies can be explained by understanding the process of
development and the role of different factors involved. The chick pancreas shares many similarities with
mammals regarding its structure and development. Thus it can serve as an effective experimental model. We
review the histomorphological development of pancreas in chick and its molecular regulation. This is to
clarify, how failure of molecular regulation in any stage is related to different congenital pancreatic
anomalies, which can be well applicable to humans.