Correlation of apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G genetic variant rs8177832 with HIV-1 predisposition in Pakistani Population

Yasir Waheed; Khurshid Iqbal; Muhammad Imran; Shafi Ullah; Muhsin Jamal; Qaisar AlI

Abstract:

Background: Human immunodeficiency virus (HIV) infection is a global health burden which ultimately results in acquired immune deficiency syndrome (AIDS). There are multiple host fac-tors which are capable of limiting HIV-1 replication. One of the most important host factors which in-hibit HIV-1 DNA synthesis is the apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G). Any genetic variation of this important host factor may influence the host suscep-tibility to viral infection. Objective: The aim of the current study was to evaluate any correlation of APOBEC3G genetic varia-tion rs8177832 with HIV-1 infection. Methods: The study involved 142 healthy control and 100 HIV-1 infected subjects. The genetic varia-tion rs8177832 of all studied subjects was determined by allele-specific polymerase chain reaction (AS-PCR). Results: The results showed that the distribution of rs8177832 genotypes AA, AG and GG in healthy subjects and HIV-1 subjects was; 42.253%, 42.957%, 14.788% and 66%, 27%, 7% respectively. Sta-tistical analyses of data showed that there was a significant variation in rs8177832 genotype AA in healthy control and HIV-1 infected subjects (42.257% vs 66%; p-value<0.001).

research from:

• Foundation University Medical College

Year:

2018

Type of Publication:

Article

Journal:

Current HIV Research

Volume:

16

Number:

4

Pages:

297-301

Month:

7

DOI:

10.2174/1570162X16666181018155827